논문검색
Author Semie Hong, Il Han Kim, Kyu Chang Wang
Place of duty 1Department of Radiation Oncology, Konkuk University College of Medicine, 2Department of Radiation Oncology, 3Institute of Radiation Medicine, Medical Research Center, 4Cancer Research Institute, 5Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea.
Title Outcome and Prognostic Factors of Childhood Diffuse Brainstem Glioma
Publicationinfo Cancer Res Treat. 2005 Apr; 037(02): 109-113.
Key_word Brainstem glioma,Radiotherapy
Full-Text
Abstract Purpose: The outcome and prognostic factors of brainstem glioma were evaluated following radiotherapy methods. Materials and Methods: Between 1986 and 2001, 45 childhood patients with diffuse brainstem glioma were treated. There were 26 boys and 19 girls, with a median age of 7 years (range 3~18). The histopathological diagnoses were confirmed in 13 patients, which revealed a low-grade glioma in four patients, and high-grade glioma in the other nine. Before 1993, radiation therapy using a regime of 1.8 to 2.0 Gy once a day was performed in 16 cases; thereafter, a regimes of 1.1 or 1.5 Gy twice a day was given in 15 and 14 cases, respectively. Nine patients were treated with adjuvant chemotherapy. The response to the treatment was evaluated by the MRI findings 4 weeks after radiotherapy. Results: After radiotherapy, the neurological deficit im-proved in 42 of the 45 patients (93%). The MRI responses were as follows; partial response 22/39 (56%), minimal to no response in 16/39 (41%) and tumor progression in 1/39 (3%). The median time to disease progression was 7 months, and the median survival was 12 months; the overall survival rate at 1 year was 41%. There was no significant prognostic factor for overall survival. The progression-free survival was influenced by the tumor histology (low grade vs. high grade, p=0.05) in those patients whose pathology was confirmed. Conclusion: The radiation therapy fractionation schedule did not influence the survival. Low grade histology was a possible favorable prognostic factor of progression-free survival in pediatric brainstem glioma patients. (Cancer Res Treat. 2005;37:109-113)